Boston Celtics pair Kemba Walker and Rob Williams have both been ruled out of Game 5 on Tuesday against the Brooklyn Nets with their NBA first round playoffs series on the line.

The Nets lead 3-1, having won 141-126 on Sunday in Game 4 over the Celtics who were without Walker (knee) and Williams (ankle).

Point guard Walker had played in Friday's 125-119 Game 3 win but is battling bone bruising in his left knee and coach Brad Stevens confirmed he would not take his place on Tuesday.

Bigman Williams only managed six minutes in Game 3 due to a sprained left ankle.

Boston are already without forward Jaylen Brown for the rest of the season due to a wrist injury, leaving a heavy burden on star Jayson Tatum.

Brooklyn can wrap up the series on Tuesday with victory and were aided by their 'big three' firing in Game 4.

Kevin Durant scored 42 points had four rebounds and five assists, while Kyrie Irving added 39 points and 11 rebounds and James Harden had 23 points and 18 assists in the win.