Uruguay's run of five straight wins came to an end after they were held to a 0-0 draw by the United States in an international friendly in Kansas City on Sunday.
Diego Godin saw an effort cleared off the line by DeAndre Yedlin as Diego Alonso's side started brightly, while at the other end Jesus Ferreira had an effort pawed away by Fernando Muslera.
FC Dallas striker Ferreira continued to look sharp during the first half, yet he was unable to find an opener before the break.
Christian Pulisic fired wide and Darwin Nunez lashed a strike just past Sean Johnson's left-hand post during a lively start to the second period.
The USA goalkeeper then made himself big to keep out Nunez's close-range effort as Uruguay looked the more likely side to seal a win.
They should have done exactly that in stoppage time, but substitute Edinson Cavani inexplicably clipped wide of an open goal after being teed up by Nunez.