Sheffield Wednesday and Charlton Athletic were the only teams to maintain their 100 per cent records in the Championship, while Reading, Stoke City and Blackburn Rovers again slipped to defeats.
Last season's relegated Premier League sides Cardiff City and Fulham both bounced back from disappointing starts with home victories, the Bluebirds beating Luton Town 2-1 and Scott Parker's side claiming a 2-0 win against Blackburn.
Middlesbrough manager Jonathan Woodgate was furious after his side had two goals disallowed in a 1-0 home defeat to Brentford, Tommy Rowe's late equaliser earned Bristol City a 1-1 draw at Birmingham City and Preston North End beat Wigan Athletic 3-0.
Meanwhile, Leeds United, QPR, West Brom and Derby County, who all won their opening games, were held to draws by Nottingham Forest, Huddersfield Town, Millwall and Swansea City respectively.
GRABBAN DENIES LEEDS ANOTHER WIN
Forest boss Sabri Lamouchi was facing the prospect of starting the season with consecutive defeats until Lewis Grabban grabbed an equaliser in a 1-1 draw with Leeds, who dominated for long spells at Elland Road.
Marcelo Bielsa's men swept Bristol City aside in the first half an hour of their season opener but found themselves embroiled in a battle with an uncompromising Forest side determined to bounce back from their 2-1 defeat at home to West Brom.
After Patrick Bamford hit the crossbar, it was playmaker Pablo Hernandez who put Leeds in front, latching onto Mateusz Klich's chipped pass over the defence and burying a shot into the far corner of the net for his second goal in as many games.
But Forest equalised with their only shot on target of the game, Grabban capitalising on a penalty-box scramble and bundling the ball over the line from close range.
TWO WINS IN TWO FOR BOWYER'S MEN
Lyle Taylor, who scored Charlton Athletic's winner in their opening-day victory over Blackburn Rovers, picked up where he left off by firing Lee Bowyer's Addicks into the lead at home against Stoke.
The Potters responded through Tom Ince, but the tireless work ethic of Bowyer's newly promoted side wore the visitors down.
Close-season signing Chuks Aneke slammed the ball into the bottom corner from close range after Josh Cullen's cut-back to make it 2-1 to the hosts, and Conor Gallagher put the result beyond doubt seven minutes from time.
OWLS OFF TO A FLYER
Loanee winger Jacob Murphy wasted little time endearing himself to the Hillsborough faithful, pouncing on a loose ball and side-footing Sheffield Wednesday into the lead after two minutes of the South Yorkshire derby against Barnsley.
The Owls carried the momentum of their victory at Reading into the game and withstood waves of pressure from a well-organised Barnsley side before doubling their lead through Steven Fletcher.
After Murphy's mazy dribble, Kieran Lee fed Fletcher and the Scotland international showed great technique with a finish into the bottom-right corner from outside the box.
FULHAM OFF THE MARK AS ROVERS FALTER
Blackburn were widely tipped to push on after finishing 15th in the Championship last season, but two games in they are still without a point following their home defeat to Charlton and a 2-0 reverse at Fulham.
Parker's side drew a blank when starting the season with a defeat at Barnsley but they went ahead against Rovers when former Blackburn midfielder Tom Cairney let rip from 25 yards.
Blackburn matched Fulham for much of the contest and Sam Gallagher squandered the chance to pull them level when he headed wide 14 minutes from time, moments before Aleksandar Mitrovic scored a tap-in.