Lucas Hernandez and Tanguy Nianzou have tested positive for COVID-19, Bayern Munich have confirmed.
The club said in a statement that the pair have entered isolation and are "both well".
They will miss Bayern's Bundesliga clash with Borussia Monchengladbach on Friday – the champions' first match after the mid-season break.
France international Hernandez has made 19 appearances across all competitions this season, while teenager Nianzou has featured in 13 games, although just four of those have been starts.
Bayern also revealed that Leroy Sane, Dayot Upamecano and Josip Stanisic returned inconclusive results.
Julian Nagelsmann's side resume Bundesliga action with a nine-point advantage over Borussia Dortmund at the top of the table.