Jed Holloway will make his Test debut and Quade Cooper returns to the Australia starting line-up for their first game of the Rugby Championship against Argentina on Saturday.
Holloway has been given the nod at blindside flanker for the game at Estadio Malvinas Argentinas, while Cooper is back at fly-half after recovering from a calf strain.
Prop Matt Gibbon is set to make his Wallabies bow off the bench in Mendoza, where hooker Folau Fainga'a makes his first international start this year.
Second row Darcy Swain has been restored to the team after serving a ban for the red card he was given for a clash with Jonny Hill in the first Test against England.
Dave Rennie's side have been licking their wounds since losing the decisive final match of the series to the Red Rose last month.
Head coach Rennie said: "We've had a strong week of preparation over here in Argentina, and we are highly motivated to put on a performance that makes our supporters proud back home in Australia.
"It's an extremely special occasion for Jed, Matt and their families, and it's up to the rest of us to make sure it's a positive memory on their Test debuts.
"Argentina will be full of confidence after their home series win over Scotland, and we know we'll need to be at our best to get a good result on Saturday afternoon."
Australia team: Tom Wright, Jordan Petaia, Len Ikitau, Hunter Paisami, Marika Koroibete, Quade Cooper, Nic White; James Slipper, Folau Fainga'a, Allan Alaalatoa, Darcy Swain, Matt Philip, Jed Holloway, Michael Hooper (captain), Rob Valetini.
Replacements: Lachlan Lonergan, Matt Gibbon, Taniela Tupou, Nick Frost, Rob Leota, Pete Samu, Jake Gordon, Reece Hodge.