Alex Cuthbert will miss Wales' two remaining Six Nations games due to a foot injury.
The wing came off the bench during defeats to Ireland and Scotland.
Cuthbert was ruled out of the 20-10 loss to England at the Principality Stadium last time out after doing damage to his foot.
The 32-year-old Ospreys flyer will play no part in a trip to face Italy at Stadio Olimpico on Saturday or Wales' final match of the tournament against France at Parc des Princes on March 18.
Louis Rees-Zammit and Josh Adams started on the wings in the defeat to England in Cardiff, the former scoring the only try for Warren Gatland's side.
Wales are bottom of the table without a point from three matches, facing a battle to avoid the Wooden Spoon.