Cristiano Ronaldo faces an uncertain Manchester United future, but he stands to pass a string of landmarks if he stays and plays for Erik ten Hag this season.
Tottenham's Harry Kane, set to captain England at the World Cup later in the year, is chasing a significant club landmark.
And guess who will join Mohamed Salah in bidding to set an opening-day career goals record.
Of course, it's...... Jamie Vardy.
As the new season gets under way on Friday, Stats Perform looks at the records and milestones coming into view.
KANE, RONALDO, HAALAND: TARGETS IN THE CROSSHAIRS OF THE BIG GUNS
What role Ronaldo has to play remains in the balance, given he appears keen to leave United for a second time.
But if the 37-year-old features for the Red Devils, he can begin to chase down landmarks. For starters, he is just four victories short of having had a hand in 150 United wins in the Premier League, having drawn 43 times and lost 37 while a member of the team across his two Old Trafford spells.
Ronaldo is a mere six goals away from becoming the first player to amass 500 goals in Europe's top five leagues. His record 494 goals to date have come from 616 league matches. On his heels, however, is perennial rival Lionel Messi, once of Barcelona and now at Paris Saint-Germain (480 goals in 546 league games).
Kane is 17 away from hitting the 200-goal mark in the Premier League, a total only ever achieved by Alan Shearer (260) and Wayne Rooney (208). Sergio Aguero (184) and Andy Cole (187), third and fourth on the Premier League era list, are poised to be knocked down a peg as Kane continues his assault on the league record.
Both Leicester City's Vardy and Liverpool's Salah will be looking to equal or break the Premier League matchday one goals record, which is currently held jointly by Shearer, Frank Lampard and Rooney (eight goals). Vardy and Salah have seven each, like the retired Teddy Sheringham and Aguero.
Manchester City new boy Erling Haaland has caused a sensation with his goalscoring wherever he has played, dazzling for Molde, Salzburg, Borussia Dortmund and Norway. He could become the seventh Norwegian to score on his Premier League debut, and the third to do so in the opening game of a season, after Tore Andre Flo for Chelsea in 1997-98 and Adama Diomande in 2016-17 with Hull City.
DESERVES A LONG SERVICE MEDAL
Liverpool's James Milner, fresh from signing a new one-year contract, is 12 short of reaching 600 Premier League games. Only three players have reached that mark to date: Gareth Barry (653), Ryan Giggs (632) and Lampard (609).
Milner made his Premier League debut for Leeds United as a 16-year-old in November 2002, so a 20-year anniversary is approaching for the former England midfielder.
David Moyes was already a Premier League manager by the time Milner made his first appearance. At Everton then, he has done the rounds since and is a mere two games away from completing 1,000 matches in all competitions as a manager in English football.
Now at West Ham, Moyes looks to be at the opposite end of his touchline career to Mikel Arteta, the Arsenal manager who is one away from bringing up his first 50 wins as a Premier League boss.
STICK AROUND LONG ENOUGH...
Only six teams have been constant members of the Premier League since its first year in 1992-93. Completing the first 30 seasons without suffering the indignity of relegation have been Manchester United, Liverpool, Chelsea, Tottenham, Everton and Arsenal. Sooner or later, all sorts of landmarks arrive for these league lynchpins.
Arsenal have lost 249 Premier League games and headed into Friday night's season opener against Crystal Palace under threat of becoming the 13th side to lose 250. They would have had the longest wait to lose 250, however, having already played four games more than Chelsea, who took the longest (1,148 games) of those to have reached the not-so-desirable milestone.
Tottenham, another of those stalwart sides, are just five away from becoming the fifth team to score 1,000 goals at home in the competition (Manchester United 1,214, Liverpool 1,156, Arsenal 1,154, Chelsea 1,121).
Chelsea are 27 shy of 2,000 goals, home or away, having plundered 1,973 in their 1,152 games to date.
Aston Villa and Newcastle United are both 12 short of losing 400 Premier League games. Only West Ham (408) and Everton (414) have lost more games than those sides, who will hope to avoid spilling over that barrier this season.
West Ham are four away from reaching 1,000 Premier League games, while promoted Nottingham Forest are two away from 200.
MAKING UP THE NUMBERS
Liverpool left-back Andy Robertson needs one assist to become only the second defender to register 50 Premier League assists, after Leighton Baines (Wigan, Everton). Robertson has 49, with Baines managing 53 across his career.
Aston Villa veteran Ashley Young and Tottenham new arrival Richarlison are two shy of reaching 50 Premier League goals, while Newcastle's former Burnley goalkeeper Nick Pope is four away from 50 clean sheets in the competition.
Brighton and Hove Albion are two away from 50 wins, with Aston Villa four short of 300 draws, a tally that only Everton (320) have reached.
Southampton need four victories to reach 100 away wins, and Aston Villa want four three-pointers on the road to reach their 150 wins. Leicester, on the other hand, are four away from 150 Premier League away defeats. Brendan Rodgers will hope to fend off that landmark until well into the new campaign.
