Zinedine Zidane left Gareth Bale and Luka Modric out of his Real Madrid squad for their Champions League trip to Galatasaray after the pair suffered injuries while on international duty.
After scoring in Wales' 1-1 draw with Croatia in Cardiff, Bale left the field limping and was later reported to be suffering from cramp, while Modric had to be substituted having sustained bruising to his right quadriceps.
The pair are joined by out-of-favour striker Mariano Diaz and calf injury victim Lucas Vazquez in missing the trip to Istanbul for a game in which Madrid badly need a win to revive their hopes of qualifying from Group A.
Los Blancos lost their opening group game 3-0 at Paris Saint-Germain and were held to a 2-2 draw by Club Brugge at Santiago Bernabeu, leaving them bottom of the group.
Tuesday's game provides Zidane's men with a chance to bounce back from their 1-0 defeat to Mallorca in LaLiga on Saturday and the Madrid coach welcomes Toni Kroos, Eden Hazard and Dani Carvajal back into his squad.