The Los Angeles Clippers will play no part in this year's playoffs, but coach Ty Lue still believes they "can be special" next season.

The Clippers finished eighth in the West to enter the Play-In tournament, only to fall short of the postseason with consecutive defeats.

After losing 109-104 to the Minnesota Timberwolves with Paul George in the lineup, the seven-time All-Star was in health and safety protocols for Friday's make-or-break 105-101 defeat at home to the New Orleans Pelicans.

George's absence was a cruel blow for the Clippers, not that playing without him is a new experience.

Injury limited George to 31 games this year – in which he averaged a team-leading 24.3 points – but that was 31 more games than the team got out of two-time NBA Finals MVP Kawhi Leonard, who is still recovering from a partial ACL tear in last season's playoff run.

Even Norman Powell, signed in February, suffered a setback and could play only limited minutes in a bench role after returning ahead of the play-in games.

Since the Clippers signed George and Leonard ahead of the 2019-20 season, they have played together in only 104 games across the regular season and playoffs.

The Clippers have a 72-32 (.692) record in those games, versus 83-71 (.539) in the 154 when one of their superstars is missing.

For that reason, Lue can retain some optimism as they hope to have Leonard back for 2022-23.

"We get our main guys back, we can be dangerous," he said after the Pelicans game. "Health is part of it. We've got to stay healthy, continue to work.

"When you get Kawhi back, a top-five player, PG, a perennial All-Star, your team changes tremendously.

"Guys who have taken on bigger roles this year, who have never been in this position before, they can kind of fall back into their original roles.

"We could be very different with those two guys back and healthy. We can be special."

The Pelicans have themselves missed a big name this year, with former first overall pick Zion Williamson joining Leonard in sitting out the entire season to date.

In his stead, C.J. McCollum and, particularly in the play-in tournament, Brandon Ingram have stepped up to lead the Pelicans into a first-round series against title favourites the Phoenix Suns.

Ingram has averaged 18.5 points per game for his career and 22.7 in the regular season this year but 28.5 across play-in wins over the San Antonio Spurs and the Clippers.

His 30 led the team on Friday, prompting high praise from coach Willie Green.

"Brandon Ingram is the truth," Green said. "He just brought it. He had that look in his eye from the time we got on the plane. Shootaround, he's been locked in. He has been waiting for this moment, for this type of moment."