Australian Open champion Novak Djokovic could face Dominic Thiem in a mouth-watering semi-final after being handed a tough path to success at Melbourne Park, where Serena Williams will continue her quest for a 24th grand slam singles title.

The Australian Open draw took place on Friday, with world number one Djokovic set to play Frenchman Jeremy Chardy in the opening round of the year's first major tournament.

Amid coronavirus concerns in Melbourne, where Swiss great Roger Federer is absent, Djokovic has set his sights on a ninth crown and 18th major success, but the top seed's title defence is far from straightforward.

Djokovic could face Gael Monfils (fourth round) and sixth seed Alexander Zverev (quarter-final) en route to a possible semi-final against US Open champion and third seed Thiem.

Who is playing who?

Women's singles draw https://t.co/EdvUSYrtla
Men's singles draw https://t.co/LHaMY6YUNY #AusOpen #AO2021 pic.twitter.com/wcUZpGve36
— #AusOpen (@AustralianOpen) February 5, 2021

The Serb overcame Thiem in a five-set thriller in last year's Australian Open final, before the latter broke through for his maiden major trophy at Flushing Meadows.

Djokovic could then meet second seed and 20-time major champion Rafael Nadal in a blockbuster final – he blitzed the Spanish superstar in the 2019 Australian Open decider but lost in three one-sided sets in their previous meeting in the French Open final.

Nadal will go head-to-head with another Serb in the first round – Laslo Djere – while Stefanos Tsitsipas could await in the quarters, with 2019 US Open final opponent Daniil Medvedev also on the same side of the draw.

Meanwhile, Williams' bid for a record-equalling 24th slam will begin against German Laura Siegemund.

The 39-year-old Williams has been stuck on 23 majors since winning the Australian Open in 2017 – losing finals at Wimbledon (2018 and 2019) and the US Open (2018 and 2019).

World number one and local hope Ashleigh Barty will meet Montenegro's Danka Kovinic in round one and defending champion Sofia Kenin faces Australian wildcard Maddison Inglis.

The last 16 could see Williams clash with Aryna Sabalenka, Barty meet Petra Martic, Kenin tackle Johanna Konta and three-time major champion Naomi Osaka do battle with last year's runner-up Garbine Muguruza.