Aaron Ramsey will miss Wales' Nations League clash with Republic of Ireland for "family reasons".
The Arsenal midfielder played the full 90 minutes in Wales' 4-1 friendly defeat to Spain on Thursday, but the Football Association of Wales has confirmed that he will sit out the match in Dublin.
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No official reason has been given for Ramsey's absence, but his wife Coleen is expecting twins.
The 27-year-old has been replaced by Swansea City's Daniel James, who had been with the Under-21 squad.
Ramsey's absence is a further blow for manager Ryan Giggs after Gareth Bale returned to Real Madrid on Sunday to recover from a groin injury, while Ethan Ampadu and Chris Mepham have also pulled out.
