Manchester United captain Harry Maguire was substituted with an apparent ankle injury in the second half of Saturday's game against Aston Villa.
Maguire was replaced by Victor Lindelof 23 minutes from time at Old Trafford, having attempted to play on.
He had early received treatment after taking a kick from Danny Ings in a tangle in the United area. Villa appealed for a penalty, but Ollie Watkins was flagged for offside earlier in the move.
Maguire's defensive colleague Luke Shaw was substituted in the first half after pulling up.
The two injuries could represent major blows to United ahead of a big week in which they will aim to get their Champions League campaign back on track at home to Villarreal.
— Manchester United (@ManUtd) September 25, 2021