Dean Henderson will make his first Premier League start for Manchester United in Saturday's match at West Ham.
Henderson replaced David de Gea at half-time during last weekend's 3-2 win at Southampton and, although the De Gea was fit to play in the midweek Champions League loss to Paris Saint-Germain, the Spain international is not in Ole Gunnar Solskjaer's matchday 18 at London Stadium.
Marcus Rashford and Bruno Fernandes drop to the bench, while Paul Pogba and Donny van de Beek will combine in a midfield anchored by Scott McTominay.
Edinson Cavani leads the United attack, flanked by Anthony Martial and Mason Greenwood, although there is no place in the squad for Fred after the midfielder's red card versus PSG.
For West Ham, Sebastien Haller replaces Michail Antonio (hamstring) in the only change from Monday's 2-1 win over Aston Villa.