Monty Williams wants to see more anger in the Detroit Pistons locker room after the team tied their franchise-record losing streak by suffering a 21st straight loss against the Philadelphia 76ers.

The NBA's worst team slumped to 2-22 with a 129-111 defeat at Little Caesars Arena on Wednesday as reigning MVP Joel Embiid finished with 41 points for the Sixers, for whom Tobias Harris added 21.

The Pistons' 21st successive defeat saw them match the worst losing run in their history, which came between the end of the 1979-80 season and the start of 1980-81.

Their current run is also the sixth-longest single-season losing streak in NBA history, and things could get worse before they get better when they travel to Philadelphia for a rematch on Friday.

Detroit were on the back foot from the start as they were outscored 39-26 in the first quarter, leading head coach Williams to demand more aggression from his team.

"I don't want anyone to be happy in this situation," Williams said.

"I want to see an ornery locker room that's tired, not just of losing, but tired of missing shots and tired of giving up 39-point quarters."

The record for the worst single-season losing streak in NBA history is held jointly by the 2010-11 Cleveland Cavaliers and the 2013-14 Sixers, both of whom lost 26 games in a row. Philadelphia also hold the overall record of 28 successive losses, set between the end of 2014-15 and start of 2015-16.

Williams was also less-than-impressed with the Pistons being outrebounded 52-35 across the course of the game, adding: "Rebounding has been a point of emphasis for 24 games… even back in the preseason.

"We have to be able to be a team that can finish a play."

While Detroit are in a rut, center James Wiseman suggested there was little they could do to stop Embiid in his current form, with the Sixers star averaging 40.8 points over his last four games.

"We tried our best," Wiseman said. "I took on the challenge and tried to contain him. We didn't back down from him."