South Africa and West Indies were frustrated by rain as Thursday's first ODI at Buffalo Park was abandoned without a ball being bowled.
The day-night match in East London was in doubt once the toss was delayed, and conditions showed little sign of significant improvement.
Although rain briefly abated, showers soon returned and the contest was called off.
The second leg of the three-match series is due to be played at the same ground on Saturday.
MATCH ABANDONED— Proteas Men (@ProteasMenCSA) March 16, 2023
Persistent rain forces the first Betway ODI to be abandoned without a ball being bowled#SAvWI #BePartOfIt pic.twitter.com/3QC2tsFvES