Odd Christian Eiking took over the red jesey from Primoz Roglic while Michael Storer claimed another solo win on stage 10 of the Vuelta a Espana.
Storer dominated the final downhill of the opening hilly stage to take victory at Rincon de la Victoria.
Having also won stage seven at Balcon de Alicante on Friday, the Australian became only the second rider from his nation to win two in a single edition of La Vuelta – after Michael Matthews in 2013.
"I was feeling good on the last climb. I knew exactly what I needed to do to win today. I had to attack," the DSM rider said.
"I didn't have exact time gaps but I knew it was tight. I had to go fast down that descent. There are dry and slippery roads in this region. I felt my descent was just enough to hold on.
"I don't realise yet that I have won two hard stages at this Vuelta after 10 days. It's actually unbelievable."
Storer finished 22 seconds ahead of Mauri Vansevenant, Clement Champoussin, Dylan van Baarle and Eiking.
Olympic champion Roglic – GC leader since the end of stage six at Alto de Cullera – went down on the slopes of Puerto de Almacher as he finished just under 12 minutes behind Storer.
That meant he surrendered La Roja to Eiking, who became only the second Norwegian leader of La Vuelta – and first since Thor Hushovd in 2006.
"I couldn't expect that this morning," he said. "I was nine minutes behind and it would almost take a miracle to be in the jersey.
"I heard on my earpiece eight minutes, nine minutes, 10 minutes. And then in the end, I understood this was really possible.
"I tried to get as many minutes as possible in the end. I can't describe what this means, it's really, really big."
1. Michael Storer (Team DSM) 4:09:21
2. Mauri Vansevenant (Deceuninck-QuickStep) +0:22
3. Clement Champoussin (AG2R Citroen) +0:22
4. Dylan van Baarle (Ineos Grenadiers) +0:22
5. Odd Christian Eiking (Intermarche-Wanty-Gobert) +0:22
1. Odd Christian Eiking (Intermarche-Wanty-Gobert) 38:37:46
2. Guillaume Martin (Cofidis) +0:58
3. Primoz Roglic (Jumbo-Visma) +2:17
1. Fabio Jakobsen (Deceuninck-QuickStep) 180
2. Jasper Philipsen (Alpecin-Fenix) 164
3. Arnaud Demare (Groupama-FDJ) 74
King of the Mountains
1. Damiano Caruso (Bahrain Victorious) 28
2. Romain Bardet (Team DSM) 22
3. Michael Storer (Team DSM) 17
The hilly stages continue on Wednesday with a 133.6km route from Antequera to Valdepenas de Jaen.