Rory McIlroy, Bryson DeChambeau and defending champion Collin Morikawa will tee off within the first two hours of the US PGA Championship, which got underway on Thursday at 07:00 local time.
Patrick Rada, Cameron Triangle, Adam Long were the first three players to tee off on Thursday at Kiawah Island's Ocean Course.
Matt Jones highlighted the second group, which teed off 11 minutes later. The Australian won this year's Honda Championship – the same competition which Rory McIlory won before dominating on this course in the PGA Championship in 2012.
McIlroy, who comes into the tournament on the back of a one-stroke victory at the Wells Fargo Championship, is in the hunt for a fifth major title.
His last win in the PGA Championship, in 2014, is his most recent of those major victories, and the Northern Irishman, currently ranked at seventh in the world, is one of the favourites.
McIlroy's average drive of 318 yards across the season so far puts him, in theory, in good stead to handle the Ocean Course, which at 7,878 yards, is the longest major track.
He is set to tee off at 08:33 local time from the first, and is paired with fellow US PGA champions Justin Thomas (2017) and Brooks Koepka (2018, 2019).
Shortly after that trio start, another big hitter in the form of 2020 US Open champion DeChambeau takes to the field. He averages 322 yards per drive this season, topping the PGA tour, though his accuracy is down at 172nd out of 215 players. That accuracy is however better than McIlroy, who ranks at 175th.
Teeing off alongside De Chambeau is Morikawa, who became the third-youngest player to win the major since it became a stroke-play event in 1958 – after McIlroy and the legendary Jack Nicklaus – when he triumphed in California last year.
The Masters champion, Hideki Matsuyama, completes a fearsome trio.
Three more previous US PGA champions will head out together later in the day, with Phil Mickelson, Jason Day and Padraig Harrington taking to the course at 13:14 in South Carolina.
They will be followed from the first by Tommy Fleetwood, world number three Jon Rahm and Patrick Reed, at approximately 13:25.
Jordan Spieth heads into the major as the only player in the field capable of completing a career grand slam this week. He starts at 13:58.
Xander Schauffele is the first top-five player due out at 08:22, while world number on Dustin Johnson is one of the later starters.
One player who will not be featuring is Francesco Molinari, who withdrew on Thursday due to a back injury.