England will be without Manu Tuilagi for their Six Nations clash with Wales after the centre suffered a hamstring injury.
Tuilagi had been set to return from an injury lay off to feature at Twickenham on Saturday, having been named in the team that Eddie Jones confirmed on Thursday.
However, England have been dealt a blow as scans after training revealed a hamstring problem for the 30-year-old.
England have recalled Joe Marchant, who will train with the squad on Friday. However, an updated team will not be confirmed until the day of the game.
Tuilagi had been set to play alongside Henry Slade in midfield for Jones' team, who bounced back from their defeat to Scotland in the opening match by beating Italy last time out.
He has represented England in 46 Tests so far since making his debut in 2011.
Squad update | Manu Tuilagi is out of this weekend's match against Wales.— England Rugby (@EnglandRugby) February 24, 2022
Joe Marchant has been recalled and will train with the squad tomorrow.
An updated team will be confirmed on match day. #ENGvWAL pic.twitter.com/GB5fLOwKCy