Steve Borthwick has left Manu Tuilagi out of his first team as England coach for the Six Nations opener against Scotland on Saturday.
Borthwick has made eight changes to the team from Eddie Jones' final game in charge against South Africa in November.
Joe Marchant has been selected at outside centre, while Marcus Smith and captain Owen Farrell are also named for the game at Twickenham.
Jamie George has come through return to play protocols to be selected at hooker.
Uncapped Ollie Hassell-Collins is one of the more surprising inclusions, while Dan Cole is named on the bench, having not played for England since the 2019 World Cup final.
After announcing the team, Borthwick detailed Tuilagi's reaction to the news, telling reporters: "Manu was the incredible professional that he is.
"We spoke, I told him what I decided selection wise... and we shook hands, and then he went and trained really hard and that reaction is testimony to him and his character and not just him but of several players in that way and ultimately what we want to build here.
"We want to build a team that is not simply about selection. It's a team that is building and going forward to try and get wins for England, which means you've got to train hard every day."
Scotland coach Gregor Townsend will hand Luke Crosbie his third cap as the Edinburgh flanker was named alongside Matt Fagerson and captain Jamie Ritchie in the back row.
Ben White will feature at scrum-half, while Kyle Steyn has been given the nod to replace the injured Darcy Graham at right wing.
Stuart Hogg has recovered from a heel injury to start at full-back, while Sione Tuipulotu and Huw Jones are named in midfield.
Steve Borthwick has named the England Men side to face Scotland on Saturday in round one of the Guinness Six Nations— England Rugby (@EnglandRugby) February 2, 2023
England team: Freddie Steward, Max Malins, Joe Marchant, Owen Farrell, Ollie Hassell-Collins, Marcus Smith, Jack van Poortvliet; Ellis Genge, Jamie George, Kyle Sinckler, Maro Itoje, Ollie Chessum, Lewis Ludlam, Ben Curry, Alex Dombrandt.
Replacements: Jack Walker, Mako Vunipola, Dan Cole, Nick Isiekwe, Ben Earl, Ben Youngs, Ollie Lawrence, Anthony Watson.
Scotland team: Stuart Hogg, Kyle Steyn, Huw Jones, Sione Tuipulotu, Duhan van der Merwe, Finn Russell, Ben White; Pierre Schoeman, George Turner, WP Nel, Richie Gray, Grant Gilchrist, Jamie Ritchie, Luke Crosbie, Matt Fagerson.
Replacements: Fraser Brown, Jamie Bhatti, Simon Berghan, Jonny Gray, Jack Dempsey, George Horne, Blair Kinghorn, Chris Harris.
Morning, Scotland fans— Scottish Rugby (@Scotlandteam) February 2, 2023
Your team to take on England in our @SixNationsRugby opener on Saturday.
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