Elliot Daly has been ruled out of England's Six Nations campaign with a hamstring injury, his club Saracens have confirmed.
Versatile back Daly withdrew from England's squad on Tuesday ahead of their opening match against Scotland at Twickenham a week on Saturday.
The 30-year-old, who sustained the injury ahead of Saracens' 20-14 Champions Cup loss to Edinburgh last week, is expected to miss around 12 weeks.
Saracens confirmed the news in a short statement on their official website on Friday, ending Daly's hopes of recovering in time to play a part.
| ?????? ??????.@elliotdaly suffered a hamstring injury in the Heineken Champions Cup match against Edinburgh.— Saracens Rugby Club (@Saracens) January 27, 2023
It is estimated he will return to action in around 12 weeks.
We’re all behind you, Elliot!#YourSaracens
England conclude their Six Nations campaign against Ireland on March 18 – seven weeks' time – as they begin a new era under head coach Steve Borthwick.
Jamie George also pulled out of England's training squad earlier this week, with Jamie Blamire and Ollie Lawrence called up as replacements.
Borthwick is also set to be without Courtney Lawes for his first match in charge at Twickenham next week, as the towering lock is struggling with a calf injury.
Hooker George McGuigan (knee) is also in the treatment room along with Luke Cowan-Dickie (ankle).
Blamire, Tom Dunn and the uncapped Jack Walker are the remaining hooker options for Borthwick.