World number three Stefanos Tsitsipas has left the Indian Wells Masters without a win after a shock 7-6 (7-0) 4-6 7-6 (7-5) loss to Jordan Thompson on Friday.
Tsitsipas, the second seed with Novak Djokovic not present, received a bye through to the second round, and he showed some rust with three double faults in the opening set.
Thompson capitalised, with an incredible 21 winners to only two unforced errors in the first set, and he closed it out with 15 winners and four unforced errors in the deciding frame for the biggest win of his career.
The Australian will now meet Chile's Alejandro Tabilo in the third round after he upset 32nd seed Maxime Cressy in a gruelling 7-6 (7-3) 7-6 (15-13) triumph.
Meanwhile, it was smooth sailing for third seed Casper Ruud in his 6-2 6-3 victory over Diego Schwartzman, and a similar story for fifth seed Daniil Medvedev in his 6-4 6-3 result against Brandon Nakashima.
Shining in #TennisParadise @DaniilMedwed knocks out Brandon Nakashima 6-4 6-3 at the @BNPPARIBASOPEN pic.twitter.com/V7COGlAgog— ATP Tour (@atptour) March 11, 2023
Alexander Zverev, the 12th seed, had no issues in his 6-3 6-1 domination of Pedro Cachin in 77 minutes, and 13th seed Karen Khachanov also took exactly 77 minutes to see off Oscar Otte 6-3 6-3.
England's 10th seed Cameron Norrie breezed past Tung-lin Wu 6-2 6-4, while Italy's 20th seed Matteo Berrettini suffered an early 7-6 (7-5) 0-6 6-3 exit at the hands of Japan's Taro Daniel.
In the late window, after a lengthy weather delay, 14th seed Frances Tiafoe won his all-American showdown against Marcos Giron 6-2 6-2.