England will be without Sean O'Loughlin, Sam Tomkins and Daryl Clark when they attempt to whitewash New Zealand on Sunday.
O’Loughlin missed the victory at Anfield last weekend due to a calf injury and the captain will remain sidelined for the clash at Elland Road.
Tomkins suffered a broken hand in a 20-14 win in Liverpool which wrapped up the series with one Test to spare.
The half-back played on after sustaining the injury in the first half, but will not feature against the Kiwis in Leeds.
Clark broke three ribs in the second Test, so the hooker will also play no part this weekend.
HOW ABOUT YESTERDAY EH?!— England Rugby League (@England_RL) November 5, 2018
An England classic and day to remember at Anfield pic.twitter.com/Lwo7xC8BZ1
Richie Myler, Joe Greenwood and Stefan Ratchford come into Wayne Bennett's matchday squad.
Head coach Bennett said England will not appeal against George Burgess' four-match ban after the prop was found guilty of eye-gouging visiting captain Dallin Watene-Zelezniak.