Andy Murray's run at the Gijon Open came to an end with a three-set loss to Sebastian Korda on Friday, dashing his hopes of a semi-final appearance in Spain.
Murray earned his fourth Tour-level quarter-final spot of 2022 by beating Pedro Cachin, but American Korda defeated the former world number one 6-4 1-6 6-1.
Korda will face Arthur Rinderknech in the last four after he upset second seed Pablo Carreno Busta, taking an epic final-set tie-break to triumph 4-6 6-3 7-6 (18-16).
The other side of the draw will play host to an enticing semi-final meeting between Dominic Thiem and top seed Andrey Rublev after they secured straight-sets wins over Francisco Cerundolo and Tommy Paul respectively.
Thiem said after his 6-4 6-3 triumph over Cerundolo: "From the first match on, I have felt great on this court.
"It is very important for me as I am trying to climb up the rankings. The semi-finals at an ATP event is helping a lot."
Meanwhile, top seed Felix Auger-Aliassime beat Brandon Nakashima 6-3 6-4 to reach the Firenze Open semi-finals, where he will face home favourite Lorenzo Musetti.
The third seed from Italy downed Mackenzie McDonald 6-3 6-2, but fellow seed Alexander Bublik went down 3-6 7-5 6-1 to J. J. Wolf.