Jofra Archer will miss both the T20 World Cup and this year's Ashes as the England bowler has been ruled out for the remainder of 2021.
Archer has been dealing with a troublesome elbow injury and underwent surgery in May, with an "intensive rehabilitation period" planned before he was reassessed.
The pace bowler insisted he would not rush his return but had targeted both the T20 World Cup – which is to be held in the United Arab Emirates and Oman – and the tour of Australia.
Archer will be available for neither, though, despite returning with Sussex last month.
The England and Wales Cricket Board announced on Thursday the player had suffered a recurrence of a stress fracture of his right elbow, confirmed by scans last week.
"In response to these findings, [Archer] has been ruled out for the rest of the year and will miss the current LV= Insurance Test series against India, the ICC Men's T20 World Cup 2021 and the Ashes series in Australia," a statement explained.
"The 26-year-old, who had an operation in May to remove a bone fragment from his elbow, returned to play last month.
"As part of his return-to-bowling programme, he became aware of increasing discomfort in his elbow during matches for Sussex in the Vitality Blast and a 50-over friendly against Oxfordshire.
"The operation is not related to the stress fracture that sidelined the player previously.
"He will now spend time on an extended break from cricket before returning for a medical review in early autumn."
England are already without all-rounder Ben Stokes for their ongoing Test series against India, as he is focusing on his mental wellbeing during an indefinite period away from the sport.
Archer starred alongside Stokes for England at the 2019 Cricket World Cup, taking 20 wickets – tied for the third-most at the tournament – to help the hosts to their first title following a dramatic final.
He was then handed his Test debut against Australia in the Ashes, collecting 22 wickets including a pair of five-fors and career-best figures of 6-45.