The Chicago Bulls will have to make do without Zach LaVine and Alex Caruso in their do-or-die Eastern Conference playoffs Game 5 showdown with the Milwaukee Bucks.

Needing a victory to keep the series alive, the Bulls confirmed LaVine and Caruso will play no part at Fiserv Forum on Wednesday.

All-Star LaVine misses out a day after he entered the NBA's health and safety protocol, having revealed he was feeling unwell before a practice session.

Fellow guard Caruso took a blow to his face in the second quarter of an emphatic 119-95 Game 4 defeat on Sunday and is going through concussion protocols.

LaVine had led the Bulls with 24 points, 13 assists and five rebounds in a loss that left them trailing the series 3-1.

A depleted Chicago were already missing Lonzo Ball (knee) and Matt Thomas (leg).