Katie Boulter stunned last year's Wimbledon runner-up Karolina Pliskova at the Eastbourne International as the Briton secured the first top-10 scalp of her career.
Despite making a strong start, fourth seed Pliskova faltered and lost 1-6 6-4 6-4 to the world number 127 in the pair's last-32 match.
Boulter said: "I'm super-proud of myself today. I went out there and didn't feel great on court, and I worked so hard to battle and fight, and against a player like that it means so much to me, coming through that."
There was another major shock win for a British player later in the day as Jodie Burrage knocked out top seed Paula Badosa, the world number 169 triumphing 6-4 6-3 against a player who will be seeded fourth at Wimbledon.
Defending champion Jelena Ostapenko beat Ajla Tomljanovic 6-4 6-4 and two-time Wimbledon winner Petra Kvitova saw off Donna Vekic 6-1 7-6 (7-1), while Beatriz Haddad Maia's strong form on grass continued with a 6-4 3-6 6-3 victory over Estonian veteran Kaia Kanepi.
Brazilian left-hander Haddad Maia is coming off the back of title wins in Nottingham and Birmingham and stretched her winning run on grass to 11 matches.
11 - Beatriz Haddad Maia is the first female player to win 11+ consecutive matches on grass since Serena Williams (20 wins in a row between Wimbledon 2015 and Wimbledon 2018). Green.@WTA @WTA_insider pic.twitter.com/MgcrekzY74
— OptaAce (@OptaAce) June 21, 2022
There were also wins in Eastbourne for Camila Giorgi, Madison Keys and Barbora Krejcikova, but Greek third seed Maria Sakkari bowed out, losing 3-6 7-5 6-4 to Ukrainian Anhelina Kalinina.
At the Bad Homburg Open in Germany, the 2019 Wimbledon champion Simona Halep scrambled for a 4-6 6-3 6-4 win against Katerina Siniakova, and sixth seed Amanda Anisimova came from a set down to see off Alison van Uytvanck in a third-set tie-break.
Bianca Andreescu saw off Martina Trevisan 6-3 6-1 and Angelique Kerber also won in straight sets, while top seed and recent French Open semi-finalist Daria Kasatkina reached the quarter-finals with a 6-1 3-6 6-1 win over Germany's Jule Niemeier.
Kasatkina will be absent from Wimbledon due to the ban on Russian players.