Swimmer Caeleb Dressel led the way with five golds as the United States finished top of the medal table at the Olympic Games for a third successive time.
Team USA's haul of 113 medals at the Tokyo Games – comprising 39 gold, 41 silver and 33 bronze – was 25 more than second-placed China, while Japan finished third.
The 58 medals won by the hosts set a record for the most they have ever won at a single Olympics, including 27 golds – 11 more than their previous record from 1964 and 2004.
Italy (40 medals), the Netherlands (36), Brazil (21), New Zealand (20), Turkey (13) and Chinese Taipei (12) also enjoyed their best ever Games showings.
In all, 93 different competing nations claimed a medal in Tokyo, which is more than any other edition of the global showpiece, surpassing the previous record of 87 set in 2008.
That includes first ever Olympic medals for Turkmenistan, San Marino and Burkina Faso in weightlifting, shooting and athletics events respectively.
Indeed, with a population of around 34,000 people, San Marino are now the smallest nation to win an Olympic medal.
MCKEON IN SEVENTH HEAVEN
Twenty of Australia's 46 medals came in the pool, with swimmer Emma McKeon responsible for seven of those – at least two more medals than any other athlete in Tokyo.
In doing so, the 27-year-old became the second female athlete to claim seven or more medals at a single Olympics after Maria Gorokhovskaya in 1952.
Dressel swept up five golds in the men's swimming events, meanwhile, to become the 10th athlete to reach that tally at a single Games.
Away from the Aquatics Centre, it was an Olympics to remember for Elaine Thompson-Herah as the Jamaican became the first woman to win both the 100 metre and 200m sprint at two Games.
Further success came for Thompson-Herah in the 4x100m relay, making her only the second woman to win five athletics golds after Allyson Felix (seven).
The Netherlands' Sifan Hassan also wrote his name in the record books by becoming the first athlete to win a medal in the 1500m (bronze), 5000m (gold) and 10,000m (gold) at the same Games.
Indeed, Hassan is the first track and field athlete to claim a medal in three individual disciplines since Carl Lewis and Heike Drechsler in 1988.
AGE IS JUST A NUMBER
Japanese skateboarder Momiji Nishiya became the youngest Olympic gold medal winner since 1960 – and third-youngest of all time – with victory in the women's street event at the age of 13 years and 330 days.
At the opposite end of the spectrum, 62-year-old Andrew Hoy of Australia became the oldest medallist at the Olympics since 1968 with a silver and bronze in the equestrian competitions.
Judokas Hifumi Abe and Uta Abe kept it in the family by becoming the first brother and sister combo to claim gold medals at the same Olympics when winning the men's -66 kilograms and women's -52kg events respectively.
July 28 proved to be a day to remember in more ways than one for Olga Frolkina and Evgeniia Frolkina, meanwhile, as the twin sisters took silver in the 3x3 basketball on their 24th birthday.