Ireland centre Garry Ringrose has been ruled out of their Six Nations trip to Italy after failing to overcome a calf injury in time.

Ringrose suffered the problem during their week two victory over holders France but was named in the starting XV for Saturday's game at Stadio Olimpico.

He has failed to overcome the issue however and has now been withdrawn, with Stuart McCloskey now in line to start and utility back Jimmy O'Brien elevated to the bench.

Andy Farrell will hope Ringrose recovers in time to take part in their final two games next month, against Scotland and England.

Ringrose had been in line to win his 50th cap for Ireland in this weekend's fixture and was looking to score on his third consecutive visit to Rome.

The centre has been a standout performer for Ireland in the Six Nations too, beating more defenders than any of his team-mates in the tournament so far, on eight occasions.

Team Update: Unfortunately Garry Ringrose has been ruled out of tomorrow’s game through injury.

Stuart McCloskey comes into the starting team, with Jimmy O’Brien named on the bench. #TeamOfUs | #GuinnessSixNations pic.twitter.com/UmureKBDnA

— Irish Rugby (@IrishRugby) February 24, 2023