Europe captain Padraig Harrington was upbeat despite his team's record Ryder Cup loss to the United States, insisting the visitors could walk away from Whistling Straits with their heads held high.

Harrington's Team Europe were no match for hosts USA, dethroned following a record-breaking 19-9 defeat in Wisconsin on Sunday.

USA claimed the Ryder Cup by a record margin, surpassing the previous 18.5 - 9.5 victory at Walton Heath Golf Club in 1981.

Europe were outclassed from the outset and Steve Stricker's USA sealed victory in just the fifth match of the scheduled 12 singles showdowns on the final day.

Team Europe had won seven of the past nine editions of the biennial event but failed to recover from a six-shot disadvantage heading into the final day as USA reigned supreme and despite the heavy defeat, Harrington could not fault his players.

19 - 9, the largest margin of victory in the modern era.#RyderCup Singles Recap
— Ryder Cup (@rydercup) September 27, 2021

"I was not aware of it until it became close," Harrington said of USA's record-winning margin. "And then I did actually have to ask. I was involved in the last two that were records [grimacing] but on the right side of it.

"Look, somebody has to. That's the way it goes. This was a very strong US Team. Everybody here gave 100 per cent, and pulled together, everybody worked together this week. There's nobody walking away from this week, and I will talk to each player individually: Nobody didn't give their heart and soul to this team.

"We don't owe anybody anything in that sense. They all tried. They all put it in. And you know, there will be more Ryder Cups ahead. Most of them – as I just said before, most of them have the best part of their career ahead of them, there's no doubt about that. So they shouldn't walk away from this in any shape or form feeling like, hey, they gave it 100 per cent. That's all you can ask from the players.

"Did they do their job? Yes, they did. It didn't go right, but that happens in sport. Just remember, you know, if you want to have these glorious moments, you've got to put your head out there, and sometimes it doesn't go right. You get your head knocked off.

"That's just the reality of sport. If you put yourself out there, you'll have some miserable days, but also, if you put yourself out there, you'll have those thrilling days when you win."