Loyola Chicago notched its second straight upset in the 2018 NCAA Tournament.

The South Region's No. 11 seed knocked off No. 3 Tennessee with a basket in the closing seconds of the game. The Ramblers defeated the Volunteers 63-62, giving Loyola its first Sweet 16 berth since 1985.

The Ramblers got off to a slow start but erased a nine-point deficit before taking a 29-25 lead into halftime. They came out even stronger for the second half, and Tennessee didn't have enough defense stop to Loyola, and the Volunteers missed several key shots.

The Volunteers, co-regular season champions in the SEC, bounced back with only a few minutes to go, but it wasn't enough to move on to the Sweet 16. Guard Clayton Custer drained a game-winning jumper with three seconds left, adding another chapter to the Cinderella story the Ramblers had already started to write.

Here are three takeaways from the upset:

1. Loyola isn't a one-hit wonder

The victory proves the team isn't a one-hit wonder following its buzzer-beating win over Miami in first-round action Thursday. Loyola knocked off No. 6 seed Miami, also in the last few seconds and also in dramatic fashion. The Ramblers (30-5) dominated the Missouri Valley Conference all season long, and while some argue Loyola didn't face a tough schedule, the players are proving they can hang with the big guys.

2. Bench players came up big for the Ramblers

While Loyola starters contributed a total of 37 points, the three player who came off the bench scored a combined 26 points for the Ramblers. Senior forward Aundre Jackson helped carry Loyola with 16 points, shooting 5-of-7 and making all six of his free-throw attempts. He also had four rebounds, one assist and one steal. Freshman guard Lucas Williamson chipped in with seven points, making two of his three 3-point attempts.

3. Sister Jean's prayers are working

The Ramblers 98-year-old chaplain Sister Jean has become more than just a fan. She leads the team in a prayer before games, she delivers a scouting report on the team they are about to face, and she even emails critiques to the players. While TNT reported on its broadcast that Sister Jean had Loyola advancing to the Sweet 16 but not getting through to the Elite Eight, she may be changing her mind about that. "I just thought they would go to the Sweet 16 and now we may even go more than that," she said. "We just go one game at a time, though."