Luis Suarez and Edinson Cavani were both on target for Uruguay on Monday and Sebastian Coates is placing his trust in the duo to come good again in the last 16 of the World Cup.
Oscar Tabarez's side secured top spot in Group A with a comfortable 3-0 win over Russia in Samara, Suarez sweeping home an early free-kick before Cavani lashed in from close range in the final minute.
In the second round, Uruguay will meet Group B runners-up Portugal, who toiled to a 1-1 draw with Iran to allow Spain to steal in and take first place.
Centre-back Coates replaced the injured Jose Gimenez alongside Diego Godin for the clash against the hosts, and dealt admirably with the considerable physical threat of Artem Dzyuba as Uruguay completed a 100 per cent group-stage campaign without conceding a goal.
"We know we have to defend and they [Suarez and Cavani] will score," Coates told reporters.
"For us, it is perfect. If we defend well, we know we will score.
"We have a good team, and you know when you see Luis and Edi running you just hit them."