Virgil van Dijk and Frenkie de Jong have left the Netherlands’ squad ahead of their final Nations League game on "medical grounds".
Both players featured in the Oranje's 4-0 victory over Hungary on Saturday, a match which confirmed their place in the quarter-finals.
Van Dijk, who has been an ever-present for Liverpool in the Premier League this season, played the full 90 minutes in Amsterdam but will return to his club for further assessment.
De Jong, meanwhile, returned to the Netherlands line-up for the first time since September 2023 in that victory, having missed the previous 18 international matches due to injuries.
The Barcelona man was taken off after 68 minutes, and had confirmed after the game that he would not be featuring on Tuesday, but has now opted to return to Spain instead of staying with the national squad.
"For both Frenkie and Virgil, it is better for them to leave the training camp at this moment. That decision was taken on medical grounds, with of course, the interest of the players coming first," Koeman is quoted as saying on the Netherlands' X account.
The Netherlands will finish second in Group A3, with their result against already relegated Bosnia-Herzegovina unable to affect the standings.
Virgil van Dijk and Frenkie de Jong are not part of the squad for our final group stage game against Bosnia and Herzegovina in the #NationsLeague.
— OnsOranje (@OnsOranje) November 18, 2024
@RonaldKoeman: “For both Frenkie and Virgil it is better for them to leave the training camp at this moment. That decision was… pic.twitter.com/EPcqG31Aux