Leeds United's home clash with Aston Villa on Tuesday has been postponed due to ongoing COVID-19 problems coinciding with injury issues within Marcelo Bielsa's squad.
Leeds fielded a depleted side in a 4-1 loss against Arsenal last Saturday before the Premier League announced Bielsa's side would not face Liverpool on Boxing Day due to having an insufficient number of first-team players to fulfil the game.
Villa were set to be Leeds' next opponents at Elland Road, but the league have accepted the Yorkshire club does not have the "required number of players available for the match (13 outfield players and one goalkeeper)".
Leeds confirmed there had been no new positive tests within the playing squad. However, the majority of those who tested positive before the Liverpool game remain in isolation.
"The league is aware that the decisions this week to postpone matches will disappoint supporters, and understands their frustrations at a special time of year when fans look forward to attending and watching football games," the Premier League's statement said.
"The league aims to provide as much clarity as possible, but unfortunately postponements sometimes have to be made at short notice, as safety is our priority.
"Where possible, the league will endeavour to keep supporters updated if matches become at risk on a matchday."
#LUFC can confirm our Premier League game with Aston Villa on 28th December 2021 has been postponed— Leeds United (@LUFC) December 26, 2021
Villa's meeting with Chelsea on Sunday remains set to go ahead, though they will be without manager Steven Gerrard after the former Liverpool midfielder tested positive for COVID-19.
The board reiterated its stance for their Premier League schedule to continue as intended following an emergency meeting between clubs on Monday, despite coronavirus ravaging fixtures throughout the top four tiers of English football.
"The board assesses applications to postpone matches on a case-by-case basis, based on existing rules and adapted COVID-19 postponement guidance, implemented in light of the new Omicron variant," the statement continued.
"While recognising a number of clubs are experiencing COVID-19 outbreaks, it is the clubs’ and the league’s collective intention to continue the current fixture schedule where safely possible.
"The health and wellbeing of all concerned remains our priority and the league will continue to monitor and reflect public health guidance, always proceeding with caution."
In total, 14 games across England's top flight have been postponed in December.