Is it time to ring the changes after a poor start or stick with the players who got you off to a flying start?
If you picked Bruno Fernandes for the opening round of Premier League fixtures, the Manchester United midfielder delivered with interest as he scored a stunning hat-trick against Leeds United.
Whether your team is sitting pretty or languishing in the lower reaches of the league, you have no doubt spent this week pondering potential selections.
Using Opta data, here are Stats Perform's Fantasy Picks that can rack up the points.
EDOUARD MENDY (Arsenal v Chelsea)
Edouard Mendy started the campaign with a clean sheet as Chelsea cruised to a 3-0 win over Crystal Palace.
The European champions face another London derby at Arsenal on Sunday and Mendy can ensure the Gunners fire a blank.
Since Thomas Tuchel replaced Frank Lampard in January, Mendy has kept more clean sheets than any other top-flight goalkeeper with 10. His clean sheet record of 53 per cent from 32 matches is the best in Premier League history for those who have played at least 10 games.
KIERAN TIERNEY (Arsenal v Chelsea)
Arsenal were beaten 2-0 by newly promoted Brentford in the first game of the campaign.
Mikel Arteta could have no complaints over Kieran Tierney's performance, with the marauding full-back creating six chances.
That was more than any other player in the opening round of fixtures and he can pose questions of the Chelsea defence in the London derby.
AARON CRESSWELL (West Ham v Leicester City)
West Ham defender Aaron Cresswell made a great start to the campaign and scored in a 4-2 victory at Newcastle United.
Cresswell has played a big part in the Hammers' success under David Moyes and is definitely one to consider picking for their home clash with Leicester City.
Since the start of last season, Cresswell has provided more assists (eight) than any other defender in the competition. No player has been involved in more goals than his tally of nine.
JOE WILLOCK (Aston Villa v Newcastle United)
Newcastle fans were delighted when Joe Willock returned to the club from Arsenal on a permanent deal following a successful loan spell last season.
Willock was not involved in a home loss to the Hammers, but can hit the ground running at Aston Villa.
The midfielder could become only the fourth player to score in eight consecutive Premier League games after ending last season in sensational form.
KEVIN DE BRUYNE (Manchester City v Norwich City)
Midfield maestro Kevin De Bruyne was restricted to a late substitute appearance as champions Manchester City were beaten at Tottenham last weekend.
Norwich City will be hoping the Belgium playmaker plays a limited role again, as he can cause all sorts of trouble if Pep Guardiola unleashes him from the start.
De Bruyne has been involved in five goals in four games against the Canaries, scoring three and setting up two. He has scored four and assisted seven in his past eight appearances versus newly promoted teams.
KELECHI IHEANACHO (West Ham v Leicester City)
Striker Kelechi Iheanacho was another player who started the Premier League as a substitute but he can make a big impact at West Ham.
He has been involved in four goals in his past four appearances against the Hammers, netting three times and providing an assist.
Iheanacho has enjoyed capital gains, scoring in his last three appearances in London.
ROBERTO FIRMINO (Liverpool v Burnley)
Brazil striker Roberto Firmino was on target in Liverpool's comfortable opening-day win at Norwich.
He has fond memories of coming up against Burnley, scoring five times and setting up a goal in his past six appearances versus the Clarets.
Firmino opened the scoring in a 3-0 victory at Turf Moor when the two sides last met in May and can strike again at Anfield.
