Romelu Lukaku lasted less than half an hour of Belgium's Nations League opener against the Netherlands on Friday.
The Chelsea forward, who endured a difficult first season back at Stamford Bridge, started up front for Roberto Martinez's side in Brussels.
But Lukaku stayed down for an extended period after tangling with Manchester City defender Nathan Ake midway through the first half.
While his Belgium team-mates appealed for a red card – or at least a foul, with Ake, the last man, not penalised – Lukaku required lengthy treatment.
The striker eventually lifted himself and continued playing but pulled up soon after when attempting to close down Frenkie de Jong.
The former Manchester United and Inter man immediately signalled he would have to be replaced, with Martinez bringing on Leandro Trossard as a substitute.