Mohamed Salah's rare penalty miss proved costly as Liverpool were beaten 1-0 by Leicester City in Tuesday's Premier League clash.
The Reds were aiming to close the gap on leaders Manchester City from six points to three, but they fell to a first defeat in 11 games in all competitions at the King Power Stadium.
Former Everton man Ademola Lookman's strike just short of the hour mark, moments after being introduced from the substitutes' bench, gave Leicester the lead after Salah had earlier had a first-half spot-kick saved.
Liverpool, who eliminated Leicester from the EFL Cup at the quarter-final stage last week, could not find a response as their run of scoring in a club-record 34 successive matches in all competitions came to an end.
Liverpool's early penalty was awarded as a result of Salah being clipped by Wilfred Ndidi in the box, but the Egypt international's attempt was kept out by Kasper Schmeichel and he headed the follow-up against the crossbar.
Schmeichel again denied Salah before half-time by palming the forward's angled drive over the frame of the goal as Leicester, who had shipped nine goals in their previous two games, continued to hold firm.
Sadio Mane wasted a big opportunity of his own when lifting the ball over the bar having been sent through on goal with 55 minutes played and those misses came back to haunt Liverpool shortly after.
The impressive Kiernan Dewsbury-Hall played in Lookman, who had only been introduced three minutes earlier, and the RB Leipzig loanee fired past Alisson at his near post after getting away from Joel Matip.
Leicester lost James Maddison to injury but showed good defensive resilience to hold on for just a second clean sheet in the league since the opening weekend of the season, inflicting another big title blow on Liverpool in the process.
Off the bench, in the goals@Alookman_ // #LEILIV pic.twitter.com/Y7iMVlECff Premier League (@premierleague) December 28, 2021