Liverpool can seal progression to the Champions League last 16 when they play on Wednesday, but Barcelona could see their exit confirmed from Europe's top competition.

Jurgen Klopp's Reds make the trip to face Ajax in Group A knowing they are guaranteed a spot in the Europa League at the very least – and simply avoiding defeat would guarantee their place in the Champions League knockout stages.

It is a more dicey affair for Xavi's Barca, however, as they welcome Bayern Munich to Camp Nou in Group C knowing a loss would spell the end of their journey. Even a win will not be enough if Inter defeat Viktoria Plzen.

Tottenham will hope to keep their noses in front in Group D, with Marseille and Sporting CP just a point behind, while Atletico Madrid have work to do in Group B.

Stats Perform previews Wednesday's eight matches by picking through the Opta data.

Ajax v Liverpool

Ajax have made for generous opponents for Liverpool of late, losing their last three against the Reds in the Champions League. Only Juventus (four, 1997-2004) and Real Madrid (seven, 2010-2019) have previously won four in a row against Ajax in the European Cup or Champions League.

Yet Ajax remain the last Dutch side to achieve a home win against Liverpool, albeit that was back in 1966, with the Premier League side unbeaten in seven subsequent trips to the Netherlands.

Liverpool's countrymen have also made hay, as Ajax have won just one of their last eight home European matches against English teams, beating Manchester City in October 2012.

With or without another strong result, this will be an historic occasion for Liverpool and Klopp, who will match Rafael Benitez's 62 Champions League matches in charge of the Reds, who bring up 150 games in the competition.

Barcelona v Bayern Munich

Needing a win, Barca might have hoped to face any team but Bayern, who have a record three Champions League away wins at the Blaugrana. Along with Juventus and Real Madrid, they are one of three teams to have won more matches at Barca than they have lost.

Home and away, Barca have lost nine of their 12 Champions League matches against Bayern, including the past five in a row.

In fact, if Bayern win again, they will match Madrid's record of 10 wins against a single opponent in the competition – Madrid's dominance coming against Bayern.

Although Bayern are already through, they are seeking a fourth home-and-away double against Barca in a Champions League season (also 1998-99, 2012-13 and 2021-22). Dynamo Kyiv (in 1997-98) are the only other team to beat Barca twice in the same campaign even once.

Tottenham Hotspur v Sporting CP

Sporting won 2-0 against Tottenham in Portugal in what was the sides' first meeting, but they have a dismal record in England, with two victories in 15 attempts away to English sides.

Spurs have won six of their seven home European matches against Portuguese opposition, only losing to Benfica in the 2013-14 Europa League.

Both of Tottenham's wins in this campaign have come at home, where Antonio Conte is bidding to become just the second Spurs coach to win each of his first three at home in the Champions League – after Harry Redknapp.

He and Tottenham will know they must keep their focus early and late; Sporting's last three Champions League goals have come in either the first or last minutes of the match, netting twice in second-half stoppage time in the reverse fixture.

Atletico Madrid v Bayer Leverkusen

Atletico have not lost at home to Leverkusen in their prior four such matches, winning two and drawing two, but the Bundesliga team have started to turn the tide, winning two in a row against them in the Champions League.

That strong home record applies whenever Atletico face German opposition, though, as Borussia Dortmund were the last Bundesliga visitors to win there in 1996. Atleti are unbeaten in 11 since.

Diego Simeone needs his team to rediscover their scoring touch, having gone three without a goal in the Champions League.

That is their worst run under Simeone. Only once in the competition have Atletico gone four without netting, back in 2009 under Abel Resino.

Other fixtures:

Club Brugge v Porto

21 – Club Brugge goalkeeper Simon Mignolet has saved all 21 of the shots on target he has faced in the Champions League this season. He has prevented a competition-leading 4.9 goals, according to expected goals on target data.

4 – Four of Porto's last seven Champions League goals have come from the penalty spot.

Inter v Viktoria Plzen

12 – Inter have scored 12 of their last 14 Champions League goals in the second halves of matches. All three against Barca last time out came after the interval – only the third time an away team has netted three second-half goals at Camp Nou in this competition.

28 – Plzen have averaged just 28 per cent of the possession in the Champions League this season, the lowest average by a team in a single season since Opta data collection began in 2003-04.

Napoli v Rangers

4 – Napoli have won all four of their matches in the Champions League this season and could become the first Italian side to win their opening five games in a single campaign since Juventus in 2004-05.

12 – No goalkeeper has faced more shots on target (29) or conceded more goals (12) than Rangers' Allan McGregor in the Champions League this season. Indeed, he has only kept four clean sheets in 21 appearances in the competition overall.

Eintracht Frankfurt v Marseille

50 – Eintracht Frankfurt's Mario Gotze could make his 50th start in the Champions League in this match. He has been involved in 25 goals in his previous 65 appearances, including 21 in his 49 starts.

3 – Marseille have won their last two games in the Champions League – both against Sporting CP – and will be looking to win three in a row for the first time since October-December 2010, when they won four on the spin under Didier Deschamps.