Lionel Messi had a hand in all six goals while Luis Suarez scored a hat-trick as Inter Miami overcame the New York Red Bulls 6-2 at Chase Stadium.
The Eastern Conference leaders were on a three-match winning streak in MLS, but fell behind to Dante Vanzeir's opener in the 30th minute.
However, the hosts turned the match on its head after the break, with Messi assisting a brace for half-time substitute Matias Rojas either side of getting on the scoresheet himself.
Suarez then took centre stage with a hat-trick inside 13 minutes - all assisted by his former Barcelona team-mate - while Emil Forsberg's stoppage-time penalty was a mere consolation for the visitors, who are now without a win in four.
Lionel Messi's six goal contributions for @InterMiamiCF tonight set a record for the most in a single game in MLS history.
— MLS Communications (@MLS_PR) May 5, 2024
Messi's five assists were also the most by a player in a game in MLS history. pic.twitter.com/wz5oPT1BBD
Data debrief
Messi broke two more MLS records following yet another inspirational display for the Herons.
The eight-time Ballon d'Or winner's six goal contributions and five assists were both the most recorded by a player in a single game.