Inter secured Champions League qualification in their penultimate game of the Serie A season, dealing a fatal blow to Atalanta's own top-four hopes with a 3-2 win at San Siro.
The Nerazzurri – finalists in Europe's premier club competition this term – stormed into a two-goal lead within just two minutes and 49 seconds after Romelu Lukaku and Nicolo Barella were on target.
Atalanta needed a result to keep their slim hopes of a top-four finish alive, and they were handed a lifeline by Mario Pasalic before the interval on Saturday.
Yet Inter added a deserved third through Lautaro Martinez after the break, making Andre Onana's late own goal a mere Atalanta consolation, as the Nerazzurri moved eight points clear of their fifth-placed visitors.
Lukaku only needed 39 seconds to put Inter ahead, timing his run from Martinez's throughball before rounding Marco Sportiello and tapping into an empty net.
Atalanta found themselves further behind by the three-minute mark, Barella hammering a rebound into the roof of the net after Sportiello twice saved from Federico Dimarco.
Hakan Calhanoglu was denied a third by the offside flag when he netted with a ferocious volley, before Onana was forced into action by Rasmus Hojlund and Teun Koopmeiners.
Atalanta halved the arrears nine minutes before half-time, Pasalic hooking a finish beyond Onana following a goalmouth scramble.
Calhanoglu drew a flying save from Sportiello as Atalanta wilted after the interval, Inter managing the game in typically assured fashion.
Martinez stretched Inter's lead further when Marcelo Brozovic teed up a tap-in 13 minutes from time, before Luis Muriel's powerful long-range strike deflected in off the unfortunate Onana as the Nerazzurri just held on for victory.