Phil Foden was a noticeable absentee from Manchester City's squad to face Wolves, while Kevin De Bruyne returned to the starting line-up.
England midfielder Foden was described as "not fully fit" by several British journalists, with boss Pep Guardiola sure to be asked for further clarification.
Guardiola made two changes to the line-up that beat Tottenham 4-2 on Thursday, with De Bruyne and Aymeric Laporte coming in as Julian Alvarez and Nathan Ake dropped to the bench for Sunday's clash at the Etihad Stadium.
The absence of Foden was the main talking point, however, having been an unused substitute for the midweek victory over Spurs, in which City had to fight back from two goals down.
Foden's last start came in the 2-1 defeat to Manchester United at Old Trafford, where he was substituted after 57 minutes.
Victory for City against Wolves would move Guardiola's side two points behind leaders Arsenal, who host Manchester United at Emirates Stadium later on Sunday.
Man City XI: Ederson; Rico Lewis, Manuel Akanji, John Stones, Aymeric Laporte; Ilkay Gundogan, Rodri; Jack Grealish, Kevin De Bruyne, Riyad Mahrez; Erling Haaland
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XI | Ederson, Lewis, Stones, Akanji, Laporte, Rodrigo, De Bruyne, Gundogan (C), Mahrez, Grealish, Haaland
SUBS | Ortega Moreno, Walker, Dias, Phillips, Ake, Cancelo, Alvarez, Bernardo, Palmer#ManCity | @HaysWorldwide pic.twitter.com/vezp0pqGMP