Colombia's winning start to the Copa America ground to a halt as they were held to a 0-0 draw by Venezuela, whose goalkeeper Wuilker Farinez kept La Tricolor's illustrious forwards at bay.
Reinaldo Rueda's side dominated the contest at Olimpico Pedro Ludovico in Goiania but failed to find a way past Venezuela's hardworking keeper.
Rueda restored Duvan Zapata and Luis Muriel to his starting line-up but the duo were frustrated as Colombia attempted 12 first-half shots without success.
The introduction of Porto winger Luis Diaz did little to improve their prospects, and he was shown a straight red card in stoppage time as Venezuela battled to a valuable point.
Yerry Mina should have opened the scoring when he stretched to meet Daniel Munoz's cross after 13 minutes but could not poke the ball into the gaping net.
Colombia continued to press and Edwin Cardona drew a good save from Farinez with a low drive from the edge of the box, and Zapata was denied in a one-on-one moments later.
Zapata burst through a line of Venezuela defenders 10 minutes before the interval but his fierce angled shot was parried away well by Farinez.
Farinez's determined display continued in the second half, when he made a fingertip save to push Mateus Uribe's spectacular overhead kick over the crossbar. The goalkeeper made eight saves in total.
The game became fractious as both sides tired, and Diaz was shown a straight red card after a clash with Francisco La Mantia, compounding Colombia's frustration.
What does it mean? Brazil poised to go top
A point for Brazil against Peru on Friday would be enough to send them top of the group, as Colombia rue their missed opportunities to claim what would have been a second win in as many Group B matches.
Cuadrado not to blame
Colombia rely on Juan Cuadrado to provide their strikers with opportunities, and the Juventus wide man did not disappoint, contributing seven key passes.
No repeat of Cardona magic
Cardona scored just before half-time to help Colombia win their Group B opener against Ecuador, but here he laboured and was substituted after 62 minutes with one shot on target to his name.
Venezuela face Ecuador in their third Zona Norte match on Sunday, while Colombia take on Peru.