Liverpool and Borussia Dortmund are preparing for home quarter-final legs knowing only victories will give them a chance of reaching the Champions League last four.
Jurgen Klopp's side were beaten 3-1 by Real Madrid in the Spanish capital last week, the scoreline matching that of the 2018 final, when Zinedine Zidane won the trophy for the third year running.
Of course, the Reds have history of famous Anfield comebacks, most notably two years ago when Barcelona were stunned on Merseyside after winning the semi-final first leg 3-0.
Dortmund are also in need of a spirited display. Marco Reus' away goal gave them a foothold in the tie against Manchester City, but a late winner from Phil Foden at the Etihad Stadium means the Premier League leaders have the advantage.
Still, if Dortmund repeat the result of the last time they hosted City in this competition, they will be going through...
Liverpool v Real Madrid (1-3 on aggregate): History on Zidane's side
Liverpool's unforgettable 4-0 win over Barcelona was one of two instances out of a possible 11 where they have progressed in a knockout tie after losing the first leg by two or more goals.
They beat Madrid by the same scoreline in March 2009 at Anfield, but Los Blancos' most recent visit to Merseyside ended in a 3-0 win in October 2014. They are now on a run of four consecutive wins over Liverpool.
Given Madrid have scored in each of their previous 23 Champions League knockout games, and the fact they have won 15 of the past 16 ties where they won the first leg by at least two goals, they would appear to be in a very strong position.
If Liverpool are to produce another turnaround, Mohamed Salah will almost certainly be key. His goal in the first leg means he has scored in each of his previous four appearances in the competition, and he could become only the second Liverpool player – after Steven Gerrard in 2007-08 – to do so in five.
Luka Modric is also chasing a small slice of history. The 2018 Ballon d'Or winner has provided an assist in three Champions League games in a row; since at least 2003-04, no Madrid player has ever managed to set up a goal in four consecutive games in this competition.
Borussia Dortmund v Manchester City (1-2 on aggregate): Haaland the main threat to Guardiola's record
Pep Guardiola lost three of his first five meetings with Borussia Dortmund but is unbeaten in his most recent seven, while City have only failed to progress twice in 15 European knockout ties after winning the first leg.
However, Guardiola endured the most recent of those eliminations, with Monaco upsetting City in his first season in charge in 2016-17. In fact, in Champions League history, the team to win the first leg 2-1 at home has been eliminated (15 times) more often than they have progressed (12).
It really could be a game of fine margins. If Dortmund repeat the scoreline from their only previous home game against City in December 2012 (1-0), that will be enough to send them through. However, City have kept clean sheets in four consecutive away games in the competition; another on Wednesday will guarantee their semi-final spot and see them become the first side to record shutouts in five games in a row since Manchester United a decade ago.
Inevitably, all eyes will be on Erling Haaland. The Norway star has only failed to score in three of his 15 Champions League appearances and has never drawn a blank at home for Dortmund, hitting seven in just four games.
Haaland has been tipped to replace Sergio Aguero at City next season, but this could be a chance for the Argentina striker to underline his legacy: a goal here will take him to 37 in the competition, the most of any player for a Premier League club. Aguero likes Bundesliga opposition, too: 11 of his 36 goals have come against sides from Germany, more than he has managed against teams from any other nation.
20 - Borussia Dortmund’s Erling Haaland has now scored 20 goals in 14 UEFA Champions League appearances; the quickest a player has ever reached 20 goals in the competition, and in 10 fewer appearances than the previous record holder (Harry Kane, 24). Astonishing. pic.twitter.com/jaUCwVmIks— OptaJoe (@OptaJoe) March 9, 2021