Arsenal are seeking clarification after Kieran Tierney was told to self-isolate due to Scotland team-mate Stuart Armstrong's positive coronavirus test.
Southampton midfielder Armstrong tested positive while on international duty and will be quarantining for 10 days.
Tierney and Ryan Christie were identified as close contacts, along with two members of Scotland's support staff, and all must now self-isolate for two weeks.
The trio will miss the Euro 2020 play-off semi-final with Israel and the Nations League matches with Slovakia and the Czech Republic.
A 14-day quarantine would also see defender Tierney sit out Arsenal's Premier League clash with Manchester City on October 17.
However, the 23-year-old insists he was socially distant from Armstrong at all times and has tested negative for COVID-19.
"I'm so disappointed and frustrated to be in this situation," he said in a statement released by the Gunners.
"I have adhered to all regulations and made sure I was socially distancing from my team-mates in the hotel. I've also tested negative. I know Arsenal and the SFA [Scottish Football Association] are now in discussions with the Scottish authorities to gain a further understanding."
Arsenal said: "Our medical team have confirmed that Kieran was socially distant at all times from the player who tested positive and has broken no rules regarding COVID-19 protocols. We are currently seeking further advice and clarification of the details."